Cedars-Sinai Medical Center has one of the largest state-of-the-art clinical research trial facilities of any private hospital in the nation.
The 164,000-square foot research facility is a freestanding building providing space for clinical and basic science research. The facility has a vivarium and operating rooms soley for research purposes. The Burns and Allen Research Institute provides a strong scientific, clinical and administration infrastructure to support these investigations. Core facilities funded by a National Institutes of Health grant provide specialized clinical research trial services.
Cedars-Sinai Medical Center ranks among the top 10 non-university hospitals nationwide receiving research funding from the National Institutes of Health.
Daniel L. Farkas, PhD, is the dedicated surgical research director. He is active and helpful in multiple on-going basic science surgical projects. Daniel R. Margulies, MD, FACS, the Trauma Medical Director, oversees the surgical trauma related research, and coordinates as needed with Dr. Farkas and the Research Institute.
Surgical residents are actively involved in trauma research activities. All categorical general surgery residents are required to complete at least one year of research and may opt to devote that year to trauma-related projects. Others participate on trauma-related clinical research throughout their clinical years.
The surgical critical care research fellow reports to Dr. Margulies for Intensive Care Unit-related research and works with trauma faculty on trauma-related Intensive Care Unit research, as do the Surgical Intensive Care Unit clinical fellows. Trauma-related research is independently done by other specialties such as orthopaedic surgery, spine trauma, neurosurgery, cardiac surgery and emergency medicine, with collaboration with the trauma faculty as needed. Trauma-related research from other clinical departments is reported at Trauma PI Committee. All IRB and IACCUC policies and procedures are strictly adhered to. Plans are also being made to expand the physical research facility capacity.
- Alban RF, Nisim AA, Ho J, Nishi, GK, Shabot MM. Readmission to surgical intensive care increases severity-adjusted patient mortality. Journal of Trauma-Injury infection & Critical Care 2006;60:1027-31
- Woo K, Magner DP, Wilson MT, Margulies DR. CT angiography in penetrating neck trauma reduces the need for operative neck exploration. American Surgeon.
- 71(9):754-8, 2005.
- Mandavia DP. Joseph A. Bedside echocardiography in chest trauma. Emergency Medicine Clinics of North America. 22(3):601-19, 2004 Aug.
- Corwin H, Levy M, Abraham E, Fink M, Gettinger A, Macintyre N, Pearl R, Shabot MM, Shapiro M. Anemia and blood transfusion in the critically ill: current clinical practice in the US -- the crit study. Critical Care Medicine 2004:32:39-52 Critical Care Medicine 2004:32:39-52
- Alban RF, Lyass S, Margulies DR, and Shabot MM. Obesity does not affect mortality after trauma. Am Surg 2006. (in press)
- Katzen TJ, Jarrahy R, Eby JB, Mathiasen RA, Margulies DR, Shahinian HK. Craniofacial and Skull Base Trauma. Journal of Trauma-Injury infection & Critical Care. 54(5):1026-34. 2003.
- Nishi GK, Suh RH, Wilson MT, Cunneen SA, Margulies DR, Shabot MM. Analysis of causes and prevention of early re-admission to surgical intensive care. American Surgeon 69(10):913-7, 2003
- Chelly MR. Margulies DR. Mandavia D. Torbati SS. Mandavia S. Wilson MT. The evolving role of FAST scan for the diagnosis of pericardial fluid. Journal of Trauma-Injury infection & Critical Care. 56(4):915-7, 2004.
- Chelly MR, Major K, Spivak J, Hui T, Hiatt JR, Margulies DR. The value of laparoscopy in management of abdominal trauma. American Surgeon. 69(11):957-60, 2003.
- Shapiro M, Gettinger A, Corwin H, Napolitano L, Levy M, Abraham E, Fink MP, MacIntyre M, Pearl R, Shabot MM. Anemia and Blood Transfusion in Trauma Patients Admitted to the ICU. Journal of Trauma-Injury infection & Critical Care 2003;55:269-274
- Major KM. Hui T. Wilson MT. Gaon MD. Shabot MM. Margulies DR. Objective indications for early tracheostomy after blunt head trauma. American Journal of Surgery. 186(6):615-9; 2003.
- Khosravi MR, Margulies DR, Alsabeh R, Nissen N, Phillips EH, Morgenstern L. Consider the diagnosis of splenosis for soft tissue masses long after any splenic injury. American Surgeon. 70(11):967-70, 2004.
- Anand N. Agreement between Orthopedic and Neurosurgeons regarding a new algorithm for the treatment of thoracolumbar injuries: a multi-center reliability study. Journal of Spinal Disorders and Techniques (in press)
- Harrop JS, Vaccaro AR, Hurlbert RJ, et al: Spine Trauma Group: Intrarater and interrater reliability and validity in the assessment of the mechanism of injury and integrity of the posterior liagmentous complex: a novel injury severity scoring system for thoracolumbar injuries. Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2005. J Neurosurg Spine 4(2):118-122, Feb 2006.
- Nisim AA, Spivak J, Margulies DR, et, al. Anomalous origin of the left main coronary artery: a rare cause of respiratory distress in an adult trauma patient with a lower extremity injury. Journal of Trauma-Injury infection & Critical Care (in press).
- Joshi N, Margulies DR. Aggressive organ donor management: more from less? Current Opinion in Organ Transplantation. 11(2):141-5, 2006.
- Plurad D, Demetriades D, Gruzinsky G, Preston C, Chan L, Gaspard D, Margulies D, Cryer G. Pedestrian injuries: the association of alcohol consumption with the type and severity of injuries and outcomes. Journal of the American College of Surgeons (in press).
- Helfet DL, Kloen P, Anand N, Rosen HS: ORIF of Delayed Unions and Nonunions of Distal Humeral Fractures Surgical Technique. J Bone and Joint Surgical Techniques, 86-A (1):18-29, March 2004
- Major K, Wilson M, Nishi GK, et al. The incidence of venous thromboembolism and DVT surveillance in the SICU. The American Surgeon 2003;69:857-861.
- Bria WF, Shabot MM. Informatics and ICU Safety. Critical Care Clinics 2004;21:55-80
- Hollingsworth-Fridlund, P., Mattice, C., Hotz, H., Martin, K., Fitzpatrick, K., Klein, J., A Trauma Performance Improvement Plan Template. Journal of Trauma Nursing. Vol. 11, No. 4 2004.
- Hotz, H.A., (Curriculum reviewer). The Electronic Library of Trauma Lectures. Society of Trauma Nurses. 2004.
- Fitzpatrick, M.K., Mattice, C., Martin, K., Hollongsworth-Fridlund, P., Hotz, H.A., Klein, J. Trauma Outcomes Performance Improvement Course manual. 2004 edition.
- Hotz, H.A., (Curriculum reviewer). Trauma Outcomes Performance Improvement Course manual. 2003 edition.
- Hotz, H.A., Henn, R., Lush, S., Hollingsworth-Fridlund, P., (eds). Advanced Trauma Care for Nurses Provider Manual. 2003 edition.
- Hotz, H.A., Henn, R., Lush, S., Hollingsworth-Fridlund, P., (eds). Advanced Trauma Care for Nurses Instructor Manual. 2003 edition.
Research is an important component of continuous improvements in patient care and survival rates in the Trauma Service and Program. Following are ongoing research projects being conducted at Cedars-Sinai Medical Center:
- Factor IX complex for the rapid reversal of coumadin anticoagulation in head injury patients
- Novel method of extubation criteria
- Immune enhancing enteral nutrition in head injured patients
- Oscillating ventilation in head trauma patients
- Post extubation laryngoscopy - prospective study
- Pneumoperitoneum after PEG placement - clinical review
- Sepsis alert early warning system
- Video intubation for emergency intubation
- Multiinstitutional study of traumatic aortic injury
- Exploratory laparotomy for ischemic bowel disease
