Fatty Diet to Reduce Myocardial Uptake During Fluorine-18-Labeled Deoxyglucose Positron-Emission Tomography (PET)
IRB Number: 11213
IRB Expiration Date: 03/31/2009
Purpose of Study
The purpose of this research study is to determine whether consumption of a high-fat and low-carbohydrate diet improves positron-emission tomography (PET) scan quality. Heart muscle artifact (artifacts are mistaken radiographic signals that appear to represent a tissue abnormality when the tissue is actually normal) during PET scan is a well-known problem that compromises the quality and accuracy of PET studies. Heart muscle artifact can create a false positive result in the chest on a total-body PET scan looking for metastatic cancer and also makes interpretation of PET scans designed to look at heart inflammation more difficult. Heart muscle artifact can negatively affect the results of PET scans, even those that do not
necessarily involve the heart. Increasing the blood fatty acid level ¿ by eating a
temporary high-fat and low-carbohydrate diet - seems to decrease heart muscle artifact; however, very little data exists to support this technique.
We are studying the impact that a high-fat and low-carbohydrate diet has on reducing heart muscle artifact during PET. If proven capable, a technique that reliably reduces heart muscle artifact on PET can benefit many future patients.
Eligibility Requirements
Eligible subjects include all inpatients and outpatients referred to Cedars-Sinai Medical Center for clinically indicated, non myocardium-directed (i.e. myocardial perfusion, function, or viability) 18FDG-PET.
Research Procedures
The following research-related procedure will be conducted during this study:
- Diet preparation for PET scan
- If you are an outpatient, you will be given instructions to eat one of three types of diets, beginning on the day before PET scan. Items in each type of diet are not experimental and will come from everyday foods familiar to you.
- If you are an inpatient, you will be given a specific diet beginning on the day before PET scan. Items in each meal are not experimental and will come from everyday foods familiar to you.
- PET scan
- This is the scan that your doctor ordered. It will be performed using the standard-of-care technique and is not affected by your participation in the study. In addition to standard-of-care evaluation of PET images for each patient, an experienced radiologist- who is not aware of the type of diet you ate leading up to your PET scan- will specifically read the images to record the amount of radionuclide sugar uptake in the heart.
Contact Information
| Nancy Zambrana |
| Study Coordinator |
| Phone: (310) 423-3763 |
| Fax: (310) 423-8396 |
